Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE007253)

Identifier
DBSNPE007253
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
818delArs9332131
Allele Name
CYP2C9*6
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C9
Description
Poor drug metabolizer, associated with lower dose requirement.
References
  1. Kidd RS, Curry TB, Gallagher S, Edeki T, Blaisdell J, Goldstein JA: Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. Pharmacogenetics. 2001 Dec;11(9):803-8. [PubMed:11740344]
  2. Allabi AC, Gala JL, Horsmans Y: CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics. 2005 Nov;15(11):779-86. [PubMed:16220110]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]