IdentifierDBSNPE007254
DrugDB01418 (Acenocoumarol)
Interacting Gene/EnzymeCytochrome P450 2C9
Gene NameCYP2C9
UniProt IDP11712
Defining Change(s)
485C>Ars72558190
Allele NameCYP2C9*15
Genotype(s)Not Available
Type(s)Effect Inferred
GroupsNon-functional CYP2C9
DescriptionPoor drug metabolizer, associated with lower dose requirement.
References
  1. Zhao F, Loke C, Rankin SC, Guo JY, Lee HS, Wu TS, Tan T, Liu TC, Lu WL, Lim YT, Zhang Q, Goh BC, Lee SC: Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose. Clin Pharmacol Ther. 2004 Sep;76(3):210-9. [PubMed:15371982 ]
  2. DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA: Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther. 2005 Dec;315(3):1085-90. Epub 2005 Aug 11. [PubMed:16099926 ]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]