Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE007255)

Identifier
DBSNPE007255
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
353_362delAGAAATGGAArs72558188
Allele Name
CYP2C9*25
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C9
Description
Poor drug metabolizer, associated with lower dose requirement.
References
  1. Maekawa K, Fukushima-Uesaka H, Tohkin M, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Saito Y, Sawada J: Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese. Pharmacogenet Genomics. 2006 Jul;16(7):497-514. [PubMed:16788382]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]