Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE007256)

Identifier
DBSNPE007256
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
374G>TNot Available
430C>TNot Available
Allele Name
CYP2C9*35
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C9
Description
Poor drug metabolizer, associated with lower dose requirement.
References
  1. Ciccacci C, Falconi M, Paolillo N, Oteri F, Forte V, Novelli G, Desideri A, Borgiani P: Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient. Pharmacogenet Genomics. 2011 Jun;21(6):344-6. doi: 10.1097/FPC.0b013e328344c340. [PubMed:21451434]
  2. Lee MY, Borgiani P, Johansson I, Oteri F, Mkrtchian S, Falconi M, Ingelman-Sundberg M: High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase. Pharmacogenomics J. 2014 Aug;14(4):343-9. doi: 10.1038/tpj.2013.41. Epub 2013 Dec 10. [PubMed:24322786]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]