Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE007258)

Identifier
DBSNPE007258
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
1080C>Grs28371686
Allele Name
CYP2C9*5
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Decreased CYP2C9
Description
Poor drug metabolizer, associated with lower dose requirement.
References
  1. Dickmann LJ, Rettie AE, Kneller MB, Kim RB, Wood AJ, Stein CM, Wilkinson GR, Schwarz UI: Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans. Mol Pharmacol. 2001 Aug;60(2):382-7. [PubMed:11455026]
  2. Allabi AC, Gala JL, Horsmans Y, Babaoglu MO, Bozkurt A, Heusterspreute M, Yasar U: Functional impact of CYP2C95, CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans. Clin Pharmacol Ther. 2004 Aug;76(2):113-8. [PubMed:15289788]
  3. Allabi AC, Gala JL, Horsmans Y: CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics. 2005 Nov;15(11):779-86. [PubMed:16220110]
  4. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]