Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 426 - 450 of 13625 in total

Methyldopa

Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading...
Approved
Matched Description: … requires biotransformation to an active metabolite for therapeutic effects. ... Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. ... [A231784] It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Teicoplanin

Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation of side chains attached to their β-D-glucosamine...
Approved
Investigational
Matched Description: … All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation ... Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … TARGOCID 200mg POWDER FOR SOLUTION FOR INJECTION/INFUSION …

Vemurafenib

Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann...
Approved
Matched Description: … After approval, Roche in collaboration with Genentech launched a broad development program. [L1012] ... Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Estrone sulfate

Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer...
Approved
Matched Iupac: … [(3aS,3bR,9bS,11aS)-11a-methyl-1-oxo-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estrone sulfate (as estropipate) is a form of estrogen. ... characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer (particularly in …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Zalcitabine

A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Description: … A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by ... This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the ... a hydrogen. …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Conestat alfa

C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Description: … C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase ... Deficiency of C1-inhibitor allows for increased plasma kallikrein activation and subsequent production ... Marketed as the product Ruconest (FDA), this drug is indicated for the treatment of acute attacks of …
Matched Categories: … Drugs Used in Hereditary Angioedema …

Ixabepilone

Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is...
Approved
Investigational
Matched Description: … It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally ... Ixabepilone is a semisynthetic analogue of epothilone B. ... Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … IXEMPRA FOR INJECTION 15 MG ... IXEMPRA (FOR INJECTION 15 MG) ... IXEMPRA FOR INJECTION 45 MG …

Upadacitinib

Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Description: … [A189165] The FDA approved upadacitinib in August 2019 and it is used for the treatment of active ... [A189165] Despite a variety of therapeutic agents available for treatment, up to 40% of the patients ... drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. …

Talbutal

Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Approved
Illicit
Matched Description: … Talbutal is a schedule III drug in the U.S. ... Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate …

Miglustat

Miglustat, commonly marketed under the trade name Zavesca, is a drug used to treat Gaucher disease. It inhibits the enzyme glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids. It is only used for patients who cannot be treated with enzyme replacement therapy with imiglucerase. Miglustat is now...
Approved
Matched Description: … in patients without a high incidence of adverse effect. ... It has recently been approved for treatment of progressive neurological symptoms in adult and pediatric ... However, clinical experience with miglustat showed that therapeutic levels of the drug could not be achieved …

Estradiol cypionate

Estradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Because of the difference in potency between estradiol and estrone, menopause (and a change in primary ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex ... Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Sotrovimab

Sotrovimab (VIR-7831), also known as GSK4182136, is a monoclonal antibody that can neutralize the SARS-CoV-2 virus. Sotrovimab was initially been granted emergency use authorization (EUA) to treat mild-to-moderate COVID-19 on May 26, 2021, based on interim results from a clinical trial, where sotrovimab was found to reduce the risk of...
Approved
Investigational
Matched Description: … [L34425, L34430, L34440] However, in April 2022, the FDA removed the EUA for sotrovimab due to the rising ... Sotrovimab (VIR-7831), also known as GSK4182136, is a monoclonal antibody that can neutralize the SARS-CoV ... authorization (EUA) to treat mild-to-moderate COVID-19 on May 26, 2021, based on interim results from a …
Matched Categories: … Antiinfectives for Systemic Use ... Approved Treatments for COVID-19 ... Experimental Unapproved Treatments for COVID-19 …
Matched Products: … Sotrovimab for Injection …

Phentermine

Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to...
Approved
Illicit
Matched Description: … [A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely ... Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity ... a new alternative that required lower doses of phentermine to obtain the desired effect. …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Posaconazole

Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Approved
Investigational
Vet approved
Matched Description: … and Aspergillus species in severely immunocompromised patients. ... Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species …
Matched Categories: … Antimycotics for Systemic Use ... Antiinfectives for Systemic Use …

Nevirapine

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Approved
Matched Description: … A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside ... analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections ... Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Ropivacaine

Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Approved
Matched Description: … It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the …
Matched Products: … ROPIVACAINE-AFT SOLUTION FOR INJECTION 1% W/V ... ROPIVACAINE-AFT SOLUTION FOR INFUSION 0.2% W/V ... ROPIVACAINE-AFT SOLUTION FOR INJECTION 0.2% W/V …

Simeprevir

Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United...
Approved
Matched Description: … Like all NS3/4A inhibitors, simeprevir is a serine protease inhibitor in similarity to [DB08873] and ... being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. ... Inhibiting HCV NS3/4A protease in a potent and highly specific manner, simeprevir is a direct-acting …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Antivirals for treatment of HCV infections …

Phenylpropanolamine

Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Approved
Vet approved
Withdrawn
Matched Description: … Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic ... Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist ... It has been used as a decongestant and appetite suppressant. …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Nasal Decongestants for Systemic Use …

Carglumic acid

Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was...
Approved
Matched Description: … Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl ... This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the …

Tavaborole

Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis...
Approved
Investigational
Matched Description: … Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, ... a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes ... protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu). …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Methimazole

Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.[L8336,L8339]...
Approved
Matched Description: … commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options ... pregnancy due to a perceived lower risk of teratogenic effects. ... Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. …

Cimetidine

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... Cimetidine has a range of pharmacological actions. ... A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. …
Matched Categories: … Medications that reduce magnesium levels ... Drugs for Acid Related Disorders ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Matched Products: … Cimetidine in Sodium Chloride ... Gaviscon All-night …

Bioallethrin

Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. A mixture containing only S-forms...
Approved
Experimental
Matched Description: … A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin ... Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an ... Bioallethrin is a synthetic pyrethroid used as a pesticide against household pest insects such as mosquitoes …
Matched Mixtures name: … Para Special Shampoo for Lice & Nits …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Plasminogen

Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond...
Approved
Matched Description: … [L34635] In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh ... Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as [fibrinolysin ... )[L34620] for the treatment of type 1 plasminogen deficiency (hypoplasminogenemia). …

Sodium aurothiomalate

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in...
Approved
Investigational
Matched Description: … Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects ... Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold ... It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence …
Displaying drugs 426 - 450 of 13625 in total