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Displaying drugs 26 - 50 of 4673 in total
PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils, enhancing their survival and activation with comparable efficacy to GM-CSF, G-CSF and EPO, which are currently used to treat anemia. However, it has been shown that when co-administered with these compounds, effects are additive, making PBI-1402...
Investigational
Matched Description: … properties are not known. PBI-1402 has a dual therapeutic action; as a chemoprotectant and hematopoietic progenitor ... PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils ... treat anemia. However, it has been shown that when co-administered with these compounds, effects are additive …
Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Xalatan manufactured by...
Approved
Investigational
Matched Synonyms: … 5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate …
Matched Description: … Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma ... hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the …
Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play...
Approved
Investigational
Matched Description: … Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression ... Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue …
Matched Mixtures name: … Kisqali Femara Co-pack ... Kisqali Femara Co-pack ... Kisqali Femara Co-pack …
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It is indicated for the management of signs and symptoms of Parkinsonian Syndrome. Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. It also causes sustained suppression of somatotropin (growth hormone) secretion...
Approved
Investigational
Matched Description: … Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity …
Matched Products: … Co Bromocriptine Capsules 5mg ... Co Bromocriptine Tablets 2.5mg …
Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate...
Approved
Investigational
Matched Description: … recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The ... Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant ... asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for …
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Approved
Investigational
Matched Description: … Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential …
Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three different factors allows it to overcome immunogenicity and unstable...
Approved
Investigational
Matched Description: … hemophilia A with factor VIII inhibitors.[A31279, L1016] It was created by Chugai Pharmaceuticals Co. Ltd. ... Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation ... and co-developed with Roche and Genentech.[L1015] …
Empagliflozin is a sodium glucose co-transporter-2 (SGLT-2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes. SGLT2 co-transporters are responsible for reabsorption of glucose from the glomerular filtrate in the kidney. The glucuretic effect resulting from SGLT2 inhibition reduces...
Approved
Matched Description: … Empagliflozin is a sodium glucose co-transporter-2 (SGLT-2) inhibitor indicated as an adjunct to diet ... control in adult patients with type 2 diabetes. SGLT2 co-transporters are responsible for reabsorption of …
Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz®. It is structurally very similar to meropenem in that it possess a 1-beta-methyl group. [Wikipedia]
Approved
Investigational
Matched Synonyms: … ydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Description: … Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz®. It is structurally very similar ... similar to meropenem in that it possess a 1-beta-methyl group. [Wikipedia] …
Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginseng's efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex...
Nutraceutical
Matched Description: … Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant …
Faropenem medoxomil is an ester prodrug derivative of the beta-lactam antibiotic faropenem. The prodrug form of faropenem offers dramatically improved oral bioavailability and leads to higher systemic concentrations of the drug. Faropenem medoxomil is a broad-spectrum antibiotic that is highly resistant to beta-lactamase degradation. It is being developed jointly by...
Investigational
Matched Description: … concentrations of the drug. Faropenem medoxomil is a broad-spectrum antibiotic that is highly resistant …
INCB-9471 is a novel, orally available CCR5 antagonist that is part of a new class of drugs to treat HIV/AIDS. It is a potent, selective inhibitor of the HIV-1 virus.
Investigational
Matched Description: … INCB-9471 is a novel, orally available CCR5 antagonist that is part of a new class of drugs to treat ... treat HIV/AIDS. It is a potent, selective inhibitor of the HIV-1 virus. …
ISS 1018 is a short, synthetic, unmethylated CpG oligodeoxynucleotide (CpG ODN) with immunostimulatory activity. ISS 1018 signals through Toll-like receptor 9 (TLR9) to induce the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin-12 (IL-12), and tumor necrosis factor - alpha (TNF-alpha) by plasmacytoid dendritic cells (pDC)....
Investigational
Matched Description: … ISS 1018 is a short, synthetic, unmethylated CpG oligodeoxynucleotide (CpG ODN) with immunostimulatory ... ISS 1018 CpG ODN promotes antigen presentation and co-stimulatory molecule expression. ISS 1018 is currently ... investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent Hepatitis B …
Calcium gluconate is a mineral supplement and medication. Supplementation is generally only required when there is not enough calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium...
Approved
Vet approved
Matched Description: … recommended by injection into a muscle. Calcium Gluconate Injection, USP is a sterile, nonpyrogenic supersaturated ... Calcium gluconate is a mineral supplement and medication. Supplementation is generally only required ... of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate. …
Biomed 101 is investigated for use/treatment in adverse effects (chemotherapy) and renal cell carcinoma. Biomed 101 is a solid. Biomed 101 binds to the leukotriene B4 receptor, but does not affect interleukin-2 antitumor activity.
Investigational
Matched Description: … (chemotherapy) and renal cell carcinoma. Biomed 101 is a solid. Biomed 101 binds to the leukotriene B4 receptor …
AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently marketed drugs. Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and...
Investigational
Matched Description: … inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown ... availability of the drug in the patient's system through a decrease in clearance and an increase in maximal blood ... therapeutic drugs for treatment of anxiety, cancer, and a number of other serious conditions. …
Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
Approved
Matched Synonyms: … 3R)-3-Hydroxy-2-((S,e)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid …
Matched Description: … bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the ... Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It …
Experimental
Matched Name: … 4-Amino-1-[(1s,3r,4r,7s)-7-Hydroxy-1-(Hydroxymethyl)-2,5-Dioxabicyclo[2.2.1]Hept-3-Yl]-5-Methylpyrimidin-2(1h)-One …
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug...
Approved
Investigational
Vet approved
Matched Description: … with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent …
Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared...
Investigational
Matched Synonyms: … (+)-calanolide A ... (+/-)-calanolide A
Matched Name: … Calanolide A
Matched Description: … Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found ... Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral ... found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs …
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Matched Description: … abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer ... mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity ... Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated …
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Approved
Investigational
Withdrawn
Matched Description: … A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide …
AV608 is a NK-1 antagonist. It is developed for the treatment of Social anxiety disorder (SAD), irritable bowel syndrome (IBS) and overactive bladder (OAB).
Investigational
Matched Description: … AV608 is a NK-1 antagonist. It is developed for the treatment of Social anxiety disorder (SAD), irritable …
Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy. Approved by the European Medicines Agency (EMA) in March 2011, Oteracil is available in combination with [DB09257] and [DB09256] within the commercially available product "Teysuno". The main active ingredient in Teysuno is [DB09256],...
Approved
Matched Description: … ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic anti-metabolite drug ... acts on rapidly dividing cancer cells. By mimicking a class of compounds called "pyrimidines" that are essential …
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. In August 2017, a combination antibacterial therapy under the market name vabomere...
Approved
Investigational
Matched Synonyms: … hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid …
Matched Description: … Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative ... components, which leads to cell death. In August 2017, a combination antibacterial therapy under the market …
Displaying drugs 26 - 50 of 4673 in total