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Displaying drugs 476 - 500 of 13625 in total

Verapamil

Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, ... arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in ... [A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Calcium glubionate anhydrous

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Approved
Matched Description: … levels in people who do not get enough calcium from their diets. ... Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium …

Daprodustat

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … [A254172] In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia. ... [A254157] A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, ... Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that …

Ciclopirox

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Description: … Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a ... synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. ... In particular, the agent is especially effective in treating Tinea versicolor. …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Salmeterol

Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, salbutamol. Salmeterol was first described in the literature in 1988. Salmeterol's structure...
Approved
Matched Description: … Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for ... [A190459] Salmeterol was first described in the literature in 1988. ... [L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 …
Matched Mixtures name: … HOVID CLEFAN-S POWDER FOR INHALATION 50/250MCG ... AIRFLUSAL FORSPIRO POWDER FOR INHALATION 50MCG/500MCG …
Matched Categories: … Drugs for Obstructive Airway Diseases …

Berotralstat

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat is strictly used to...
Approved
Matched Description: … Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary ... [L26661] It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the ... FDA on December 3, 2020, as the first once-daily oral therapy to prevent angioedema attacks of HAE in …
Matched Categories: … Drugs Used in Hereditary Angioedema …

Beremagene geperpavec

Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Description: … [L46916] DEB is caused by mutations in the _COL7A1_ gene that encodes collagen VII (COL7), a major component ... [A259771] Beremagene geperpavec is genetically modified to deliver _COL7A1_, thereby restoring the levels ... of the anchoring fibrils for dermal–epidermal cohesion. …

Polidocanol

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural...
Approved
Matched Description: … The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization ... in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity ... (n) of approximately 9 and a mean molecular weight of approximately 600. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Sclerosing Agents for Local Injection …

Octocrylene

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin...
Approved
Investigational
Matched Description: … Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and ... Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing ... However, the use of this chemical doesn’t just stop with sunscreen for face and arms, but can extend …
Matched Mixtures name: … Hope In A Jar Broad Spectrum SPF 25 Sunscreen and Moisturizer for All Skin Types ... Hope In A Jar SPF 25 ... Renewed Hope In A Jar SPF 30 …

Demeclocycline

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Description: … Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer ... A tetracycline analog having a 7-chloro and a 6-methyl. …
Matched Categories: … Antibiotics for Topical Use ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Pegaptanib

Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.
Approved
Investigational
Matched Description: … Pegaptanib is a polynucleotide aptamer. ... Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces …
Matched Categories: … Vascular Endothelial Growth Factor A …

Rozanolixizumab

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange. It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly generalized myasthenia...
Approved
Investigational
Matched Description: … [A260207] AChR is vital for signal transduction in the neuromuscular junctions (NMJ) by generating ... [A260177] It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly ... [L47122] In June 2023, Rozanolixizumab-noli was approved by the FDA under Priority Review for the treatment …

Sulconazole

Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis infections.[L44592,L44597] Sulconazole appears to be effective...
Approved
Matched Description: … Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream ... [L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial ... derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Ambenonium

Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Approved
Matched Description: … Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. …

Florbetapir (18F)

Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Description: … that plays a key role in Alzheimer's Disease pathogenesis. ... who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline. ... Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography (PET) imaging …

Oxyquinoline

Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Approved
Vet approved
Matched Description: … It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products. ... Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and …
Matched Mixtures name: … INDIO (111-IN) OSSINA CURIUM NETHERLANDS …
Matched Categories: … Antiinfectives and Antiseptics for Local Oral Treatment …

Pyrantel

Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm infections including ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis . Pyrantel was initially described in 1965 by researchers from Pfizer who sought cyclic amidines with suitable pharmacokinetic properties (specifically, duration of action) for use...
Approved
Vet approved
Matched Description: … Pyrantel is mainly available in formulations for dogs and cats as the embonate salt, containing a 34.7% ... Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm ... pharmacokinetic properties (specifically, duration of action) for use as an anthelmintic drug. …
Matched Mixtures name: … Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbs ... Heartgard Plus Chewable Tablet for Dogs - 26 - 50 lbs ... Heartgard Plus Chewable Tablet for Dogs - 51 - 100 lbs …

Cefixime

Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis,...
Approved
Investigational
Matched Description: … [A263026] However, cefixime is not recommended as a first-line of treatment for uncomplicated urogenital ... [A263031] Cefixime was first approved in the United States in 1986.[L49293] ... Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Phenyl salicylate

Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in DB00945 ). Phenyl salicylate may...
Approved
Matched Description: … It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing ... Phenyl salicylate is used as a food additive in the USA [L2479]. ... salicylate (found in [DB00945] ). …

Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Approved
Investigational
Matched Description: … Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor ... Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast …
Matched Categories: … Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …

Ivosidenib

Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Description: … a positive opinion of ivosidenib and recommended it be granted marketing authorization for the treatment ... Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. ... [L48781] In February 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Setmelanotide

Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies. It is an agonist of the melanocortin 4 receptor. Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. Other...
Approved
Investigational
Matched Description: … attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in ... [A224449] Other earlier treatments for these patients included gastric bypass surgery. ... Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin …

Boric acid

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical ... in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes ... Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nabilone

Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … for such a wide variety of medical conditions. ... It is also approved for use in treatment of anorexia and weight loss in patients with AIDS. ... It was approved in 1985 by the United States FDA for treatment of chemotherapy-induced nausea and vomiting …

Cortisone acetate

Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.[A226300,L13203] Cortisone acetate...
Approved
Investigational
Matched Iupac: … -hydroxy-9a,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. ... [A226295] Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory …
Matched Categories: … Corticosteroids for Systemic Use …
Displaying drugs 476 - 500 of 13625 in total