Displaying drugs 551 - 575 of 13626 in total
Fondaparinux
Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in heparin and HS...
Approved
Investigational
Matched Description: … The monomeric sequence in heparin and HS is thought to form the high affinity binding site for the natural ... a O-methyl group at the reducing end of the molecule. ... Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and …
Matched Products: … ARIXTRA 12.5MG/ML SOLUTION FOR INJECTION ... ARIXTRA 2.5MG/0.5ML SOLUTION FOR INJECTION ... Arixtra Solution for Injection 7.5 mg/0.6 ml …
Matched Products: … ARIXTRA 12.5MG/ML SOLUTION FOR INJECTION ... ARIXTRA 2.5MG/0.5ML SOLUTION FOR INJECTION ... Arixtra Solution for Injection 7.5 mg/0.6 ml …
Methylcellulose
Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3,...
Approved
Matched Description: … It is available under a variety of trade names as a treatment for constipation. ... Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water ... and emulsifier for foodstuffs and cosmetics. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Drugs for Constipation …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Drugs for Constipation …
Thonzylamine
Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with DB04837 or DB00388 for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.
Approved
Matched Description: … It is available as combination products with [DB04837] or [DB00388] for temporary relief of symptoms …
Matched Categories: … Antihistamines for Topical Use ... Antihistamines for Systemic Use …
Matched Categories: … Antihistamines for Topical Use ... Antihistamines for Systemic Use …
Tirzepatide
Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … [L41820] Later, it was approved under a different brand name ZEPBOUND on November 8, 2023, for the chronic ... [A246260]
Tirzepatide comprises a 39 amino acid linear synthetic peptide conjugated to a C20 fatty ... weight management in adults with obesity or overweight with at least one weight-related condition. …
Matched Categories: … Drugs Used in Diabetes …
Matched Categories: … Drugs Used in Diabetes …
Sulfasalazine
Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into mesalazine and sulfapyridine, 2 compounds that carry out the main pharmacological...
Approved
Matched Description: … [A255582]
Sulfasalazine was first used in 1940 for rheumatic polyarthritis, and has been firmly established ... trials in 1950 but regained interest from the clinical community in the late 1970. ... Meta-analysis of 19 randomized controlled trials indicated that sulfasalazine is superior to placebo in …
Avacincaptad pegol
Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule. It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA). AMD is the leading cause of vision loss in developed countries for people over 50 years old, with...
Approved
Investigational
Matched Description: … [L47696] AMD is the leading cause of vision loss in developed countries for people over 50 years old, ... for GA. ... with a global estimate of 170 million individuals affected. …
Loxoprofen
Loxoprofen is a propionic acid derivative non-steroidal anti-inflammatory drug. It is marketed under the trade name Loxonin in Brazil, Mexico and Japan by Sankyo, as Loxomac in India, and as Oxeno in Argentina. A transdermal preparation was approved for use in Japan in January 2006.
Approved
Matched Description: … A transdermal preparation was approved for use in Japan in January 2006. ... Loxoprofen is a propionic acid derivative non-steroidal anti-inflammatory drug. ... , and as Oxeno in Argentina. …
Matched Categories: … Topical Products for Joint and Muscular Pain ... Antiinflammatory Preparations, Non-Steroids for Topical Use …
Matched Categories: … Topical Products for Joint and Muscular Pain ... Antiinflammatory Preparations, Non-Steroids for Topical Use …
Simethicone
Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed. Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
Approved
Matched Description: … [A228308]
Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952 ... [A228308] It has a favourable safety profile as it is not systemically absorbed. ... Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Ovol for Gas 80 Mg Tablet ... Ovol for Gas 180 Mg Tablet ... Ovol for Gas 180 Mg Capsule …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Ovol for Gas 80 Mg Tablet ... Ovol for Gas 180 Mg Tablet ... Ovol for Gas 180 Mg Capsule …
Flunisolide
Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors.
Approved
Investigational
Matched Description: … Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions ... It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves …
Matched Categories: … Medications that reduce magnesium levels ... Corticosteroids for Systemic Use ... Drugs for Obstructive Airway Diseases …
Matched Categories: … Medications that reduce magnesium levels ... Corticosteroids for Systemic Use ... Drugs for Obstructive Airway Diseases …
Methylphenobarbital
A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Approved
Matched Description: … It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital ... A barbiturate that is metabolized to phenobarbital. …
Meperidine
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Description: … A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including …
Matched Products: … PETHIDINE-HAMELN 50MG/ML SOLUTION FOR INJECTION ... Pethidine-hameln Solution for Injection 50mg/ml …
Matched Products: … PETHIDINE-HAMELN 50MG/ML SOLUTION FOR INJECTION ... Pethidine-hameln Solution for Injection 50mg/ml …
Cilgavimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … December 9, 2021, for the pre-exposure prophylaxis of COVID-19 in individuals at increased risk for ... [A243356, A243361] Cilgavimab (formerly AZD1061) is a recombinant monoclonal antibody produced in Chinese ... hamster ovary (CHO) cells derived from a neutralizing antibody isolated from a patient with a natural …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Experimental Unapproved Treatments for COVID-19 …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Experimental Unapproved Treatments for COVID-19 …
Tixagevimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … December 9, 2021, for the pre-exposure prophylaxis of COVID-19 in individuals at increased risk for ... [A243356, A243361] Tixagevimab (formerly AZD8895) is a recombinant monoclonal antibody produced in Chinese ... hamster ovary (CHO) cells derived from a neutralizing antibody isolated from a patient with a natural …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Experimental Unapproved Treatments for COVID-19 …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Experimental Unapproved Treatments for COVID-19 …
Pralsetinib
Pralsetinib, similar to the previously approved selpercatinib, is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small cell lung cancer. Although multikinase inhibitors, including cabozantinib, ponatinib,...
Approved
Investigational
Matched Description: … including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in ... specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. ... Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced …
Opium
Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was...
Approved
Illicit
Matched Description: … It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years ... Morphine is the most prevalent and principal alkaloid in opium, and it is responsible for most of the ... There is some legal production of opium in different countries for the obtention of alkaloids by extraction …
Nimodipine
Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking...
Approved
Investigational
Matched Description: … Nimodipine is a 1,4-dihydropyridine calcium channel blocker. ... acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in ... By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth …
Matched Products: … NIMOTOP FOR INFUSION 0.02% …
Matched Products: … NIMOTOP FOR INFUSION 0.02% …
Technetium Tc-99m succimer
Technetium Tc-99m (99mTc) succimer, also known as technetium Tc-99m dimercaptosuccinic acid (DMSA), is a radioactive diagnostic agent used to evaluate functional renal tissue and tubular function in patients with renal parenchymal disorders. It works by binding to the cortical region of the kidneys. Technetium Tc-99m succimer is used with gamma...
Approved
Matched Description: … >99mTc) succimer, also known as technetium Tc-99m dimercaptosuccinic acid (DMSA),[A245643] is a ... radioactive diagnostic agent used to evaluate functional renal tissue and tubular function in patients ... [L40558] The use of technetium Tc-99m succimer for the detection of kidney cortical defects was first …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Miltefosine
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. It can be administered topically or orally and...
Approved
Investigational
Matched Description: … The CDC has also recommended it as a first line treatment for free-living amebae (FLA) infections such ... developed in the 1980s as an anti-cancer agent. ... It can be administered topically or orally and is only indicated in patients aged 12 years or older. …
Clonazepam
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796]
Since being...
Approved
Illicit
Matched Description: … for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history in the ... of prescriptions are written for the medication internationally every year. ... A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive …
Riluzole
A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Approved
Investigational
Matched Description: … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Pentoxyverine
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors.
The...
Approved
Investigational
Withdrawn
Matched Description: … It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and ... The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. ... Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic …
Matched Mixtures name: … Pancold A …
Matched Mixtures name: … Pancold A …
Parathyroid hormone
Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids...
Approved
Investigational
Matched Description: … Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic ... fractures and is marketed in Europe by Nycomed. ... Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. …
Calcitriol
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to DB00169 (vitamin D3)...
Approved
Nutraceutical
Matched Description: … It is also available in topical form for the treatment of mild to moderate plaque psoriasis in adults ... Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing ... Administered orally and intravenously, calcitriol is commonly used as a medication in the treatment of …
Matched Categories: … Antipsoriatics for Topical Use …
Matched Categories: … Antipsoriatics for Topical Use …
Idelalisib
Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab...
Approved
Matched Description: … For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with ... Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic ... rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Drospirenone
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Description: … Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination ... [A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the ... Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic …
Matched Categories: … Hormonal Contraceptives for Systemic Use …
Matched Categories: … Hormonal Contraceptives for Systemic Use …
Displaying drugs 551 - 575 of 13626 in total