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An IgG1 murine monoclonal anti-idiotype antibody (Ab2), ACA-125, was developed to bind to anti-CA 125 antibodies. ACA-125 mimics the tumor-associated antigen CA-125, which can be detected in about 80% of ovarian carcinomas. This new concept of oncological immunotherapy consists of an attempt to trigger the immune system of the host...
Investigational
Matched Description: … developed to bind to anti-CA 125 antibodies. ACA-125 mimics the tumor-associated antigen CA-125, which can be ... create ACA-125, a hybridoma cell was adapted to serum-free medium and antibody was produced in a hollow fiber …
Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Investigational
Matched Description: … Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125. …
Matched Categories: … CA-125 Antigen …
Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a...
Approved
Matched Description: … anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition ... Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic ... Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible …
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered...
Approved
Matched Synonyms: … 6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid ... ((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid ... methylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure …
Matched Description: … Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and ... it is administered in combination with cilastatin, a renal dipeptidase inhibitor. [PubChem] …
Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a reddish-orange light,...
Approved
Matched Description: … Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is ... element in the universe by mass but a rare element on Earth. It displays a reddish-orange light, and is commonly …
Matched Mixtures name: … Co-NE-O2-N2 Mixture ... Lung Diffusion Test Mix No Ne Co
Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that is slightly less dense than air. It is toxic to hemoglobic animals (including humans) when encountered in concentrations above about 35 ppm, although it is also produced in normal animal metabolism in low quantities, and is thought to have...
Approved
Matched Synonyms: … CO
Matched Description: … Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that is slightly less dense than air …
Matched Mixtures name: … Co-NE-O2-N2 Mixture ... Co-HE-O2-N2 Mixture ... Lung Diffusion Test Mix No Ne Co
Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Synonyms: … 2.2.1]hept-3-yl]-1H-benzimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}- …
Matched Description: … Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat ... by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into ... effective against genotypes 1a, 1b, 4a, and 5a and with a lesser activity against genotypes 2a and 3a of HCV …
Ubidecarenone, also known as Coenzyme Q10, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail. This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the...
Experimental
Matched Description: … capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it ... Ubidecarenone, also known as Coenzyme Q10, is a 1,4-benzoquinone, where Q refers to the quinone chemical ... eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates …
Matched Mixtures name: … Co-q10 and Vitamin E …
Matched Products: … Biomed Co Q 10 ... Co Q 10 - 50mg Cap ... Co-enzyme Q-10 …
Dorzolamide is a carbonic anhydrase (CA) inhibitor. It is used in ophthalmic solutions (Trusopt) to lower intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension.
Approved
Matched Description: … Dorzolamide is a carbonic anhydrase (CA) inhibitor. It is used in ophthalmic solutions (Trusopt) to lower …
Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C...
Approved
Investigational
Matched Description: … binding to cardiac troponin C in a calcium-dependent manner. It also has a vasodilatory effect, by opening ... Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart ... calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts …
A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. [PubChem]
Approved
Matched Synonyms: … 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol ... alpha-Bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol …
Matched Description: … A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been …
N-[(2S,4S,6R)-2-(dihydroxymethyl)-4-hydroxy-3,3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamide is a solid. This compound belongs to the penicillins. These are organic compounds containing the penicillin core structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2, and an amide group at position 6 [starting from the sulfur atom at position 1]. This...
Experimental
Matched Name: … N-[(2S,4S,6R)-2-(dihydroxymethyl)-4-hydroxy-3,3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamide …
Matched Description: … 3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamide is a solid. This compound belongs to the ... structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2 …
Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.
Investigational
Matched Description: … Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary …
Ibalizumab is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing the entry of HIV particles into lymphocytes. It is the most-advanced antibody in development for the treatment of HIV/AIDS.
Investigational
Matched Description: … Ibalizumab is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells …
RP101 is targeted at preventing tumor cells from developing resistance to chemotherapy, one of the most challenging areas facing oncologists. RP101 would be used as a co-treatment with cytostatic drugs to give a broader range of chemotherapy treatment options, thereby extending survival periods and improving quality of life for the...
Investigational
Matched Description: … oncologists. RP101 would be used as a co-treatment with cytostatic drugs to give a broader range of chemotherapy …
Alfimeprase is a recombinant analog of fibrolase. Fibrolase is a zinc-containing metalloproteinase isolated from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix). It is a small protein that contains 203 residues (Randolph et al. 1992). Alfimeprase is being developed by Nuvelo.
Investigational
Matched Description: … Alfimeprase is a recombinant analog of fibrolase. Fibrolase is a zinc-containing metalloproteinase isolated ... (Agkistrodon contortrix contortrix). It is a small protein that contains 203 residues (Randolph …
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
Experimental
Matched Synonyms: … Co-galactoisomerase ... Co-waldenase …
Matched Description: … A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized ... as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids …
Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.
Approved
Matched Synonyms: … Desglucolanatoside A
Matched Description: … Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart …
Ergoloid mesylate is a dihydrogenated ergot (Claviceps purpurea) derivative alkaloid used as a vasodilator agent. Ergoloid Mesylate is the only vasodilator that has shown mild benefits in the treatment of vascular dementia. Ergoloid Mesylate is a mixture of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. It has been proposed to...
Approved
Matched Synonyms: … co-dergocrine mesilate ... co-dergocrine mesylate ... co-dergocrine methanesulfonate …
Matched Description: … Ergoloid mesylate is a dihydrogenated ergot (Claviceps purpurea) derivative alkaloid used as a vasodilator agent ... treatment of vascular dementia. Ergoloid Mesylate is a mixture of three different ergotamantriones: dihydroergocornine ... and dihydroergocryptine. It has been proposed to be a neuroprotective agent. The mechanism of its therapeutic …
PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils, enhancing their survival and activation with comparable efficacy to GM-CSF, G-CSF and EPO, which are currently used to treat anemia. However, it has been shown that when co-administered with these compounds, effects are additive, making PBI-1402...
Investigational
Matched Description: … properties are not known. PBI-1402 has a dual therapeutic action; as a chemoprotectant and hematopoietic progenitor ... PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils ... treat anemia. However, it has been shown that when co-administered with these compounds, effects are additive …
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Approved
Vet approved
Matched Description: … A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. …
Biapenem has been used in trials studying the treatment of Bacterial Infections.
Investigational
Biapenem has been used in trials studying the treatment of Bacterial Infections.
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. [PubChem]
Approved
Matched Synonyms: … )-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid ... [((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid …
Matched Description: … A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, …
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem]
Experimental
Matched Description: … A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is ... is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem] …
AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently marketed drugs. Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and...
Investigational
Matched Description: … inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown ... availability of the drug in the patient's system through a decrease in clearance and an increase in maximal blood ... therapeutic drugs for treatment of anxiety, cancer, and a number of other serious conditions. …
Displaying drugs 1 - 25 of 4238 in total