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Axicabtagene ciloleucel is a chimeric antigen receptor (CAR) T cell therapy for the treatment of Diffuse large B-cell lymphoma (DLBCL), which is a type of a non-Hodgkin lymphoma (NHL). It is the second cell-based gene therapy that is FDA-approved but the first in the treatment of large B-cell lymphoma in...
Approved
Matched Description: … Axicabtagene ciloleucel is a chimeric antigen receptor (CAR) T cell therapy for the treatment of Diffuse ... Diffuse large B-cell lymphoma (DLBCL), which is a type of a non-Hodgkin lymphoma (NHL). It is the second ... collected. The modified version of the T-cell expresses a new gene that targets and kills the lymphoma cells …
Tisagenlecleucel is a CD19-directed genetically modified autologous T cell immunotherapy, or a CAR-T cell therapy for B-cell acute lymphoblastic leukemia. It was granted approval by FDA in August 2017 under the market name Kymriah. Tisagenlecleucel is an immunocellular therapy that involves autologous T cells that are collected from each individual...
Approved
Matched Synonyms: … CAR.CD19-Redirected T cells …
Matched Description: … Tisagenlecleucel is a CD19-directed genetically modified autologous T cell immunotherapy, or a CAR-T cell therapy ... engineered to express a specific protein called a chimeric antigen receptor (CAR) that specifically target ... receptors (CD19 CAR-T cells) direct the T cells to targt and kill leukiemia cells that express a specific antigen …
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered...
Approved
Matched Synonyms: … 6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid ... ((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid ... methylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure …
Matched Description: … Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and ... it is administered in combination with cilastatin, a renal dipeptidase inhibitor. [PubChem] …
Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is colorless, odorless, inert and monatomic. It is the fifth most abundant chemical element in the universe by mass but a rare element on Earth. It displays a reddish-orange light,...
Approved
Matched Description: … Neon is a chemical element with a chemical symbol Ne and atomic number 10. It is a noble gas that is ... element in the universe by mass but a rare element on Earth. It displays a reddish-orange light, and is commonly …
Matched Mixtures name: … Co-NE-O2-N2 Mixture ... Lung Diffusion Test Mix No Ne Co
Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that is slightly less dense than air. It is toxic to hemoglobic animals (including humans) when encountered in concentrations above about 35 ppm, although it is also produced in normal animal metabolism in low quantities, and is thought to have...
Approved
Matched Synonyms: … CO
Matched Description: … Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that is slightly less dense than air …
Matched Mixtures name: … Co-NE-O2-N2 Mixture ... Co-HE-O2-N2 Mixture ... Lung Diffusion Test Mix No Ne Co
Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Synonyms: … 2.2.1]hept-3-yl]-1H-benzimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}- …
Matched Description: … Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat ... by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into ... effective against genotypes 1a, 1b, 4a, and 5a and with a lesser activity against genotypes 2a and 3a of HCV …
Ubidecarenone, also known as Coenzyme Q10, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail. This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the...
Experimental
Matched Description: … capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it ... Ubidecarenone, also known as Coenzyme Q10, is a 1,4-benzoquinone, where Q refers to the quinone chemical ... eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates …
Matched Mixtures name: … Co-q10 and Vitamin E …
Matched Products: … Biomed Co Q 10 ... Co Q 10 - 50mg Cap ... Co-enzyme Q-10 …
A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. [PubChem]
Approved
Matched Synonyms: … 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol ... alpha-Bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol …
Matched Description: … A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been …
N-[(2S,4S,6R)-2-(dihydroxymethyl)-4-hydroxy-3,3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamide is a solid. This compound belongs to the penicillins. These are organic compounds containing the penicillin core structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2, and an amide group at position 6 [starting from the sulfur atom at position 1]. This...
Experimental
Matched Name: … N-[(2S,4S,6R)-2-(dihydroxymethyl)-4-hydroxy-3,3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamide …
Matched Description: … 3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamide is a solid. This compound belongs to the ... structure, which is structurally characterized by a penam ring bearing two methyl groups at position 2 …
Ibalizumab is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing the entry of HIV particles into lymphocytes. It is the most-advanced antibody in development for the treatment of HIV/AIDS.
Investigational
Matched Description: … Ibalizumab is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells …
RP101 is targeted at preventing tumor cells from developing resistance to chemotherapy, one of the most challenging areas facing oncologists. RP101 would be used as a co-treatment with cytostatic drugs to give a broader range of chemotherapy treatment options, thereby extending survival periods and improving quality of life for the...
Investigational
Matched Description: … oncologists. RP101 would be used as a co-treatment with cytostatic drugs to give a broader range of chemotherapy …
Ergoloid mesylate is a dihydrogenated ergot (Claviceps purpurea) derivative alkaloid used as a vasodilator agent. Ergoloid Mesylate is the only vasodilator that has shown mild benefits in the treatment of vascular dementia. Ergoloid Mesylate is a mixture of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. It has been proposed to...
Approved
Matched Synonyms: … co-dergocrine mesilate ... co-dergocrine mesylate ... co-dergocrine methanesulfonate …
Matched Description: … Ergoloid mesylate is a dihydrogenated ergot (Claviceps purpurea) derivative alkaloid used as a vasodilator agent ... treatment of vascular dementia. Ergoloid Mesylate is a mixture of three different ergotamantriones: dihydroergocornine ... and dihydroergocryptine. It has been proposed to be a neuroprotective agent. The mechanism of its therapeutic …
Alfimeprase is a recombinant analog of fibrolase. Fibrolase is a zinc-containing metalloproteinase isolated from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix). It is a small protein that contains 203 residues (Randolph et al. 1992). Alfimeprase is being developed by Nuvelo.
Investigational
Matched Description: … Alfimeprase is a recombinant analog of fibrolase. Fibrolase is a zinc-containing metalloproteinase isolated ... (Agkistrodon contortrix contortrix). It is a small protein that contains 203 residues (Randolph …
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
Experimental
Matched Synonyms: … Co-galactoisomerase ... Co-waldenase …
Matched Description: … A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized ... as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids …
PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils, enhancing their survival and activation with comparable efficacy to GM-CSF, G-CSF and EPO, which are currently used to treat anemia. However, it has been shown that when co-administered with these compounds, effects are additive, making PBI-1402...
Investigational
Matched Description: … properties are not known. PBI-1402 has a dual therapeutic action; as a chemoprotectant and hematopoietic progenitor ... PBI-1402 is a small molecule synthetic compound with oral Bioavailability. The compound activates neutrophils ... treat anemia. However, it has been shown that when co-administered with these compounds, effects are additive …
Biapenem has been used in trials studying the treatment of Bacterial Infections.
Investigational
Biapenem has been used in trials studying the treatment of Bacterial Infections.
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. [PubChem]
Approved
Matched Synonyms: … )-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid ... [((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid …
Matched Description: … A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, …
AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently marketed drugs. Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and...
Investigational
Matched Description: … inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown ... availability of the drug in the patient's system through a decrease in clearance and an increase in maximal blood ... therapeutic drugs for treatment of anxiety, cancer, and a number of other serious conditions. …
Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared...
Investigational
Matched Synonyms: … (+)-calanolide A ... (+/-)-calanolide A
Matched Name: … Calanolide A
Matched Description: … Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found ... Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral ... found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs …
A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem]
Experimental
Matched Description: … A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is ... is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem] …
A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications. [PubChem]
Experimental
Matched Description: … A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical …
Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and...
Approved
Vet approved
Matched Description: … Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent …
Matched Mixtures name: … Co-NE-O2-N2 Mixture ... Co-HE-O2-N2 Mixture ... Lung Diffusion Test Mix No Ne Co
Matched Products: … Nitrogen c70f6047-a0cb-4f70-aa3a-78acd681efc3 …
Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play...
Approved
Matched Description: … Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression ... Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue …
Matched Mixtures name: … Kisqali Femara Co-pack ... Kisqali Femara Co-pack ... Kisqali Femara Co-pack …
Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Xalatan manufactured by...
Approved
Investigational
Matched Synonyms: … 5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate …
Matched Description: … Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma ... hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the …
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Approved
Investigational
Matched Description: … Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential …
Displaying drugs 1 - 25 of 4239 in total