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Investigational
Matched Name: … CAT-213 …
Matched Description: … CAT-213 is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic …
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Investigational
Matched Description: … Labetuzumab is a humanized monoclonal antibody to carcinoembryonic antigen that inhibits tumor growth …
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Experimental
Matched Synonyms: … caproyl-CoA ... caproyl-coenzyme A ... Hexanoyl-Coenzyme A
Matched Name: … Hexanoyl-CoA
Matched Categories: … Coenzyme A
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Investigational
Matched Description: … TAK-475 is a "squalene synthase inhibitor", a type of cholesterol-lowering drug that has not yet been …
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Experimental
Matched Synonyms: … 3-Acetoacetyl-CoA ... Acetoacetyl coenzyme A ... Acetoacetyl-Coenzyme A
Matched Name: … Acetoacetyl-CoA
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Nutraceutical
Matched Synonyms: … CoA ... CoA-SH …
Matched Name: … Coenzyme A
Matched Description: … coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester, such as acetyl-CoA) as ... Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidation ... as a substrate. In humans, CoA biosynthesis requires cysteamine, pantothenate, and adenosine triphosphate …
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Experimental
Matched Synonyms: … propanoyl-coenzyme A ... Propionyl coenzyme A ... Propionyl-CoA
Matched Name: … Propanoyl-CoA
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Experimental
Matched Description: … compactin. Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity ... 000 times greater than the HMG-CoA substrate itself. Mevastatin is a pro-drug that is activated by in ... Mevastatin or compactin is a cholesterol-lowering agent isolated from Penicillium citinium. It …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Experimental
Matched Description: … attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. [PubChem] ... A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities …
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Withdrawn
Matched Description: … market, due to reports of fatal Rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Approved
Matched Description: … hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic ... cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to ... disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Approved
Matched Description: … Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with ... activity. Its potency is similar to "propranolol":http://www.drugbank.ca/drugs/DB00571. …
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Approved Investigational
Matched Synonyms: … (1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-py …
Matched Description: … hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol ... acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times ... times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Experimental
Matched Name: … 3r-Hydroxydecanoyl-Coa
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Experimental
Matched Name: … (S)-Hmg-Coa
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Approved
Matched Description: … Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the ... the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin ... Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Approved
Matched Description: … hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic ... cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Approved
Matched Description: … A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. [PubChem] …
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Experimental
Matched Name: … Myristoyl-Coa
Matched Categories: … Coenzyme A
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Approved
Matched Synonyms: … 8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid …
Matched Description: … Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. ... the first statin discovered. It is a ring-opened dihydroxyacid with a 6’-hydroxyl group that does not require ... cells, increased selectivity for hepatic tissues, and a reduction in side effects compared with lovastatin …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Approved
Matched Description: … Bopindolol (INN) is a beta blocker. It is an ester which acts as a prodrug for "pindolol":http://drugbank.ca/drugs/DB00960 …
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Experimental
Matched Synonyms: … 4-hydroxybenzoyl CoA ... 4-Hydroxybenzoyl-CoA ... 4-Hydroxybenzoyl-coenzyme A
Matched Name: … 4-Hydroxybenzoyl Coenzyme A
Matched Categories: … Coenzyme A
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Approved
Matched Synonyms: … 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl …
Matched Description: … terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl ... Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus ... (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It …
Matched Categories: … Hydroxymethylglutaryl-CoA Reductase Inhibitors …
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Approved Vet_approved
Matched Description: … A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia …
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Approved
Matched Description: … b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. It is also shown to inhibit …