A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
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Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
J Biol Chem. 2003 Feb 28;278(9):7234-9. Epub 2002 Dec 18.
- PubMed ID
- 12493763 [ View in PubMed]
- Abstract
Eukaryotic genes are under the control of regulatory complexes acting through chromatin structure to control gene expression. Here we report the identification of a family of multiprotein corepressor complexes that function through modifying chromatin structure to keep genes silent. The polypeptide composition of these complexes has in common a core of two subunits, HDAC1,2 and BHC110, an FAD-binding protein. A candidate X-linked mental retardation gene and the transcription initiation factor II-I (TFII-I) are components of a novel member of this family of complexes. Other subunits of these complexes include polypeptides associated with cancer causing chromosomal translocations. These findings not only delineate a novel class of multiprotein complexes involved in transcriptional repression but also reveal an unanticipated role for TFII-I in transcriptional repression.