Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.
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Cho S, Choi YJ, Kim JM, Jeong ST, Kim JH, Kim SH, Ryu SE
Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.
FEBS Lett. 2001 Jun 1;498(1):62-6.
- PubMed ID
- 11389899 [ View in PubMed]
- Abstract
The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1alpha regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1alpha. PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway.