Protein kinase cdelta in apoptosis: a brief overview.
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Zhao M, Xia L, Chen GQ
Protein kinase cdelta in apoptosis: a brief overview.
Arch Immunol Ther Exp (Warsz). 2012 Oct;60(5):361-72. doi: 10.1007/s00005-012-0188-8. Epub 2012 Aug 24.
- PubMed ID
- 22918451 [ View in PubMed]
- Abstract
Protein kinase C-delta (PKCdelta), a member of the lipid-regulated serine/threonine PKC family, has been implicated in a wide range of important cellular processes. In the past decade, the critical role of PKCdelta in the regulation of both intrinsic and extrinsic apoptosis pathways has been widely explored. In most cases, over-expression or activation of PKCdelta results in the induction of apoptosis. The phosphorylations and multiple cell organelle translocations of PKCdelta initiate apoptosis by targeting multiple downstream effectors. During apoptosis, PKCdelta is proteolytically cleaved by caspase-3 to generate a constitutively activated catalytic fragment, which amplifies apoptosis cascades in nucleus and mitochondria. However, PKCdelta also exerts its anti-apoptotic and pro-survival roles in some cases. Therefore, the complicated role of PKCdelta in apoptosis appears to be stimulus and cell type dependent. This review is mainly focused on how PKCdelta gets activated in diverse ways in response to apoptotic signals and how PKCdelta targets different downstream regulators to sponsor or restrain apoptosis induction.