IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.
Article Details
- CitationCopy to clipboard
Rolling C, Treton D, Pellegrini S, Galanaud P, Richard Y
IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.
FEBS Lett. 1996 Sep 9;393(1):53-6.
- PubMed ID
- 8804422 [ View in PubMed]
- Abstract
IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.