Common polymorphisms in the coding part of the IL4-receptor gene.
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Deichmann K, Bardutzky J, Forster J, Heinzmann A, Kuehr J
Common polymorphisms in the coding part of the IL4-receptor gene.
Biochem Biophys Res Commun. 1997 Feb 24;231(3):696-7.
- PubMed ID
- 9070874 [ View in PubMed]
- Abstract
We present 12 common polymorphisms in the coding part of the IL4 receptor gene, 5 of them leading to amino acid changes of the gene product. The IL4-receptor represents a membrane bound protein on T-cells binding the cytokine IL4 and mediating its effect. The polymorphisms and mutations described here might be useful to shed light on the structure and functioning of the IL4 receptor. Furthermore, the protein represents a candidate gene for several immunological disorders involving the IL4 pathway.