Solution structure of human IL-13 and implication for receptor binding.
Article Details
- CitationCopy to clipboard
Moy FJ, Diblasio E, Wilhelm J, Powers R
Solution structure of human IL-13 and implication for receptor binding.
J Mol Biol. 2001 Jun 29;310(1):219-30.
- PubMed ID
- 11419948 [ View in PubMed]
- Abstract
Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable therapeutic target. The high-resolution solution structure of human IL-13 has been determined by multidimensional NMR. The resulting structure is consistent with previous short-chain left-handed four-helix bundles, where a significant similarity in the folding topology between IL-13 and IL-4 was observed. IL-13 shares a significant overlap in biological function with IL-4, a result of the common alpha chain component (IL-4Ralpha) in their respective receptors. Based on the available structural and mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for forming the signaling heterodimer is proposed for IL-13.