Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside.

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Goettl VM, Wemlinger TA, Fong TG, Neff NH, Hadjiconstantinou M

Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside.

Brain Res. 2000 Sep 15;877(1):1-6.

PubMed ID

10980236 [ View in PubMed

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Abstract

Selected cholinergic and dopaminergic markers were compared in the retina of aged (20-22-months-old) and young (3-months-old) rats before and after treatment with GM1 ganglioside. The dopaminergic markers, tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid were comparable in the young and aged animals and GM1 treatment did not alter them. In contrast, mazindol binding, a marker for the dopamine transporter, was diminished in the aged retina and treatment with GM1 restored binding to values found in the young animals. The cholinergic markers choline acetyltransferase and hemicholinium-3 binding, a marker for the high-affinity choline transport, were depressed in aged rats and GM1 corrected the deficits.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Mazindol	Sodium-dependent dopamine transporter	Protein	Humans	Yes	Inhibitor	Details