Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.

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Hashimoto T, Ohata H, Honda K

Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.

J Pharmacol Sci. 2006 Jan;100(1):82-7. Epub 2006 Jan 11.

PubMed ID

16404130 [ View in PubMed

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Abstract

Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 - 100 microg/site) led to increased plasma exudation in the skin. The LPA-induced plasma exudation was inhibited by ketotifen, a histamine H1-receptor antagonist, and diacylglycerol pyrophosphate (DGPP), a LPA1/LPA3-receptor antagonist. Moreover, pretreatment with pertussis toxin and DGPP inhibited the histamine release from peritoneal mast cells induced by LPA. These findings indicate that plasma exudation induced by LPA is mediated by histamine release from mast cells via LPA receptor(s), presumably LPA1 and/or LPA3, coupled to G(i/o) proteins. Moreover, these findings point to a role of LPA in the pathomechanisms of various allergic disorders.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ketotifen	Histamine H1 receptor	Protein	Humans	Yes	Antagonist	Details