Structure of influenza haemagglutinin at the pH of membrane fusion.
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Bullough PA, Hughson FM, Skehel JJ, Wiley DC
Structure of influenza haemagglutinin at the pH of membrane fusion.
Nature. 1994 Sep 1;371(6492):37-43.
- PubMed ID
- 8072525 [ View in PubMed]
- Abstract
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.