Structure of a human common cold virus and functional relationship to other picornaviruses.
Article Details
- CitationCopy to clipboard
Rossmann MG, Arnold E, Erickson JW, Frankenberger EA, Griffith JP, Hecht HJ, Johnson JE, Kamer G, Luo M, Mosser AG, et al.
Structure of a human common cold virus and functional relationship to other picornaviruses.
Nature. 1985 Sep 12-18;317(6033):145-53.
- PubMed ID
- 2993920 [ View in PubMed]
- Abstract
We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.