A different genetic code in human mitochondria.
Article Details
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Barrell BG, Bankier AT, Drouin J
A different genetic code in human mitochondria.
Nature. 1979 Nov 8;282(5735):189-94.
- PubMed ID
- 226894 [ View in PubMed]
- Abstract
Comparison of the human mitochrondial DNA sequence of the cytochrome oxidase subunit II gene and the sequence of the corresponding beef heart protein shows that UGA is used as a tryptophan codon and not as a termination codon and suggests that AUA may be a methionine and not an isoleucine codon. The cytochrome oxidase II gene is contiguous at its 5' end with a tRNAAsp gene and there are only 25 bases at its 3' end before a tRNALys gene. These tRNA'S are different from all other known tRNA sequences.