Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton.
Article Details
- CitationCopy to clipboard
Akita Y
Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton.
FEBS J. 2008 Aug;275(16):3995-4004. doi: 10.1111/j.1742-4658.2008.06557.x. Epub 2008 Jul 11.
- PubMed ID
- 18637120 [ View in PubMed]
- Abstract
Recent studies have established essential roles of protein kinase Cepsilon in signaling pathways controlling various functions of microfilaments and intermediate filaments by modulating multiple cytoskeletal proteins. This review summarizes recent progress in our understanding of the roles of protein kinase Cepsilon in the functions and signaling of microfilaments and intermediate filaments, with a focus mainly on cell-matrix and cell-cell interactions, migrations and contraction, in addition to its relevance in the development of several diseases, such as malignant tumors or cardiac disease.