Structure and chromosomal localization of the human PD-1 gene (PDCD1).
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Shinohara T, Taniwaki M, Ishida Y, Kawaichi M, Honjo T
Structure and chromosomal localization of the human PD-1 gene (PDCD1).
Genomics. 1994 Oct;23(3):704-6.
- PubMed ID
- 7851902 [ View in PubMed]
- Abstract
A cDNA encoding mouse PD-1, a member of the immunoglobulin superfamily was previously isolated from apoptosis-induced cells by subtractive hybridization. To determine the structure and chromosomal location of the human PD-1 gene, we screened a human T cell cDNA library by mouse PD-1 probe and isolated a cDNA coding for the human PD-1 protein. The deduced amino acid sequence of human PD-1 was 60% identical to the mouse counterpart, and a putative tyrosine kinase-association motif was well conserved. The human PD-1 gene was mapped to 2q37.3 by chromosomal in situ hybridization.