Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
Article Details
- CitationCopy to clipboard
Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, et al.
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
Science. 1994 May 13;264(5161):965-8.
- PubMed ID
- 8178155 [ View in PubMed]
- Abstract
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.