Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family.
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Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M
Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family.
J Immunol. 2001 Nov 15;167(10):5517-21.
- PubMed ID
- 11698418 [ View in PubMed]
- Abstract
Some CD2 family receptors stimulate NK cell-mediated cytotoxicity through a signaling pathway, which is dependent on the recruitment of an adapter protein called SLAM-associated protein (SAP). In this work we identify a novel leukocyte cell surface receptor of the CD2 family called CD2-like receptor activating cytotoxic cells (CRACC). CRACC is expressed on cytotoxic lymphocytes, activated B cells, and mature dendritic cells, and activates NK cell-mediated cytotoxicity. Remarkably, although CRACC displays cytoplasmic motifs similar to those recruiting SAP, CRACC-mediated cytotoxicity occurs in the absence of SAP and requires activation of extracellular signal-regulated kinases-1/2. Thus, CRACC is a unique CD2-like receptor which mediates NK cell activation through a SAP-independent extracellular signal-regulated kinase-mediated pathway.