Cloning and functional expression of a human parathyroid hormone receptor.
Article Details
- CitationCopy to clipboard
Schneider H, Feyen JH, Seuwen K, Movva NR
Cloning and functional expression of a human parathyroid hormone receptor.
Eur J Pharmacol. 1993 Jul 15;246(2):149-55.
- PubMed ID
- 8397094 [ View in PubMed]
- Abstract
We have cloned a human receptor for parathyroid hormone from a kidney complementary DNA library. The deduced sequence of 593 amino acids shows high homology to the previously cloned receptors from opossum and rat. Expressed in COS-1 cells, the human receptor binds to parathyroid hormone-(1-38) with high affinity (pKD = 8.5) and is functionally coupled to adenylate cyclase (pEC50 = 9.4). At high concentrations of agonist, the receptor also activates phosphoinositide turnover.