A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle.
Article Details
- CitationCopy to clipboard
van der Flier A, Kuikman I, Baudoin C, van der Neut R, Sonnenberg A
A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle.
FEBS Lett. 1995 Aug 7;369(2-3):340-4.
- PubMed ID
- 7544298 [ View in PubMed]
- Abstract
The mRNA's of several integrin subunits are alternatively spliced in the region encoding cytoplasmic domains, that may potentially provide alternative integrin-cytoskeleton interactions and transmembrane signaling pathways. We identified a novel cytoplasmic tail variant of the human beta 1 subunit by reverse transcriptase polymerase chain reaction. This fourth beta 1 variant, named beta 1D, is specific for skeletal and cardiac muscle. The determined genomic organization of the 3'-region of the human beta 1 gene reveals that beta 1D is produced by alternative splicing of mRNA. In addition, we show that the expression of beta 1D is developmentally regulated during murine myoblast differentiation, suggesting a role for beta 1D in myogenesis.