Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.
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Capon DJ, Seeburg PH, McGrath JP, Hayflick JS, Edman U, Levinson AD, Goeddel DV
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.
Nature. 1983 Aug 11-17;304(5926):507-13.
- PubMed ID
- 6308467 [ View in PubMed]
- Abstract
Kirsten (Ki)-ras cDNA clones were prepared from human lung and colon carcinoma cell lines expressing an activated c-Ki-ras2 gene. DNA sequence analysis and transfection studies indicate that different point mutations at the same codon can activate the gene; that most human c-Ki-ras2 mRNA uses sequences from a fourth coding exon distinct from that of its viral counterpart; and that at least one cell line is functionally homozygous for the activated gene.