Altered membrane permeability as the basis of bactericidal action of methdilazine.
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Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R
Altered membrane permeability as the basis of bactericidal action of methdilazine.
J Antimicrob Chemother. 1998 Jul;42(1):83-6.
- PubMed ID
- 9700532 [ View in PubMed]
- Abstract
The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Methdilazine Histamine H1 receptor Protein Humans YesAntagonistDetails