Do ethanol and metronidazole interact to produce a disulfiram-like reaction?
Article Details
- CitationCopy to clipboard
Williams CS, Woodcock KR
Do ethanol and metronidazole interact to produce a disulfiram-like reaction?
Ann Pharmacother. 2000 Feb;34(2):255-7.
- PubMed ID
- 10676835 [ View in PubMed]
- Abstract
OBJECTIVE: To obtain and evaluate evidence about the supposed disulfiram-like interaction between metronidazole and ethanol. DATA SOURCES: MEDLINE search from January 1964 to June 1999, using the terms metronidazole, ethanol, and drug reaction. DATA SYNTHESIS: The manufacturer's warnings include a disulfiram-like reaction between metronidazole and ethanol. However, review of reports published between 1969 and 1982 produced no convincing evidence that this reaction exists. Six case reports involving eight patients were evaluated. CONCLUSIONS: Four of the eight cases were serious, including one death, but the authors of all the reports presumed the metronidazole-ethanol reaction to be an established pharmacologic fact. None provided evidence that could justify their conclusions.
DrugBank Data that Cites this Article
- Drugs
- Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareTipranavirMetronidazole The risk or severity of adverse effects can be increased when Metronidazole is combined with Tipranavir.