Desmoteplase in the treatment of acute ischemic stroke.
Article Details
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Dafer RM, Biller J
Desmoteplase in the treatment of acute ischemic stroke.
Expert Rev Neurother. 2007 Apr;7(4):333-7.
- PubMed ID
- 17425487 [ View in PubMed]
- Abstract
Desmoteplase, developed by Paion, Forest and Lundbeck, is a novel plasminogen activator that selectively activates fibrin-bound plasminogen and is currently being investigated for the treatment of acute ischemic stroke within the time window of 3-9 h after symptom onset. Desmoteplase is believed to offer pharmacologic advantages over currently approved treatment options. To date, two published Phase II perfusion imaging-based clinical trials have reported the safety and potential efficacy of desmoteplase in ischemic stroke. Results from a recently completed Phase III trial in Europe, Asia and the USA are awaited. This article reviews the available data on desmoteplase, including discussion of its favorable features and potential benefit beyond the 3-h time window in the treatment of ischemic stroke.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Desmoteplase Plasminogen Protein Humans UnknownNot Available Details