Prolonged sporadic hemiplegic migraine associated with a novel de novo missense ATP1A2 gene mutation.
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De Sanctis S, Grieco GS, Breda L, Casali C, Nozzi M, Del Torto M, Chiarelli F, Verrotti A
Prolonged sporadic hemiplegic migraine associated with a novel de novo missense ATP1A2 gene mutation.
Headache. 2011 Mar;51(3):447-50. doi: 10.1111/j.1526-4610.2010.01793.x. Epub 2010 Nov 4.
- PubMed ID
- 21352219 [ View in PubMed]
- Abstract
Hemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6-year-old boy affected by sporadic hemiplegic migraine, showing a novel ATP1A2 gene missense mutation (p.Gly715Arg) in exon 16. Long-term treatment with flunarizine resulted in good clinical response and prevention of further attacks.