The structure of efrotomycin.

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Dewey RS, Arison BH, Hannah J, Shih DH, Albers-Schonberg G

The structure of efrotomycin.

J Antibiot (Tokyo). 1985 Dec;38(12):1691-8.

PubMed ID
4093333 [ View in PubMed
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Abstract

The antibiotic efrotomycin (I), C59H88N2O20, was isolated from cultures of Nocardia lactamdurans as an amorphous yellow powder. Mass spectral and NMR analyses show that the compound is a glycoside of the known antibiotic aurodox (II), C44H62N2O12. Ozonolysis and hydrolysis of I produced the disaccharide V, 6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha -L-mannopyranosyl)-3-O-methyl-beta-D-allopyranose. This disaccharide is attached to the 4-hydroxyl group of the hexahydropyran substructure of aurodox via a beta-linkage to C-1 of the allose.

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