Involvement of the brain type of ryanodine receptor in T-cell proliferation.
Article Details
- CitationCopy to clipboard
Hakamata Y, Nishimura S, Nakai J, Nakashima Y, Kita T, Imoto K
Involvement of the brain type of ryanodine receptor in T-cell proliferation.
FEBS Lett. 1994 Sep 26;352(2):206-10.
- PubMed ID
- 7523185 [ View in PubMed]
- Abstract
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.