Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.
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Kuhen KL, Shen X, Samuel CE
Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.
Gene. 1996 Oct 31;178(1-2):191-3.
- PubMed ID
- 8921913 [ View in PubMed]
- Abstract
The pkr gene encoding the interferon-inducible, RNA-dependent protein kinase was isolated as lambda phage and P1 phage clones from human genomic DNA and characterized by restriction mapping, Southern blot analysis, and nucleotide sequencing. The genomic nucleotide sequence, when compared to that of previously determined cDNA sequences, revealed 17 exons encoding the 551-amino-acid PKR protein. We report herein the sequence of the human PKR protein kinase deduced from genomic clones.