Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis.
Article Details
- CitationCopy to clipboard
Ha CH, Jin ZG
Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis.
Mol Cells. 2009 Jul 31;28(1):1-5. doi: 10.1007/s10059-009-0109-9. Epub 2009 Jul 20.
- PubMed ID
- 19655095 [ View in PubMed]
- Abstract
Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angiogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.