Emerging roles for the non-canonical IKKs in cancer.
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Shen RR, Hahn WC
Emerging roles for the non-canonical IKKs in cancer.
Oncogene. 2011 Feb 10;30(6):631-41. doi: 10.1038/onc.2010.493. Epub 2010 Nov 1.
- PubMed ID
- 21042276 [ View in PubMed]
- Abstract
The IkappaB Kinase (IKK)-related kinases TBK1 and IKKvarepsilon have essential roles as regulators of innate immunity by modulating interferon and NF-kappaB signaling. Recent work has also implicated these non-canonical IKKs in malignant transformation. IKKvarepsilon is amplified in approximately 30% of breast cancers and transforms cells through the activation of NF-kappaB. TBK1 participates in RalB-mediated inflammatory responses and cell survival, and is essential for the survival of non-small cell lung cancers driven by oncogenic KRAS. The delineation of target substrates and downstream activities for TBK1 and IKKvarepsilon has begun to define their role(s) in promoting tumorigenesis. In this review, we will highlight the mechanisms by which IKKvarepsilon and TBK1 orchestrate pathways involved in inflammation and cancer.