Organization of the genes encoding the human proteasome activators PA28alpha and beta.
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McCusker D, Wilson M, Trowsdale J
Organization of the genes encoding the human proteasome activators PA28alpha and beta.
Immunogenetics. 1999 May;49(5):438-45.
- PubMed ID
- 10199920 [ View in PubMed]
- Abstract
Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent with gene duplication during vertebrate evolution. The intron/exon organization of both genes was highly conserved, the major difference being the absence of the exon encoding the lysine and glutamic acid-rich 'KEKE' motif in PA28beta. Two other genes of relevance to the immune system were located close to those for PA28 at 14q11.2 including ISGF3G, a protein involved in transcription after IFNalpha signalling. These sequences were also characterized.