Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes.

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Gutkind GO, Ogueta SB, de Urtiaga AC, Mollerach ME, de Torres RA

Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes.

J Antimicrob Chemother. 1990 May;25(5):751-8.

PubMed ID

2115510 [ View in PubMed

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Abstract

Purified membranes of Listeria monocytogenes ATCC 15313 contain at least five penicillin-binding proteins. In two dicloxacillin-resistant mutants, derived from a sensitive parent strain, a 16-fold increase in the MIC of dicloxacillin was observed. A less-significant increase was detected in the MICs of other beta-lactam drugs. In the mutants, PBP 3 lost its strong affinity for dicloxacillin, but remained fully susceptible to binding of 125I-penicillin X, as compared with the wild-type strain. PBP 2 could not be detected in one of the mutants. No decrease in affinity for the radioactive tracer or dicloxacillin was detected in any other PBP of the resistant mutants.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dicloxacillin	Penicillin-binding protein 3	Protein	Listeria monocytogenes serotype 4b str. LL195	Yes	Inhibitor	Details