Human hTM alpha gene: expression in muscle and nonmuscle tissue.
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MacLeod AR, Gooding C
Human hTM alpha gene: expression in muscle and nonmuscle tissue.
Mol Cell Biol. 1988 Jan;8(1):433-40.
- PubMed ID
- 3336363 [ View in PubMed]
- Abstract
We have isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle alpha-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM alpha gene, which is distinct from the hTMnm gene encoding a closely related isoform of skeletal muscle alpha-tropomyosin. In cultured human fibroblasts, the hTM alpha gene encodes both skeletal-muscle- and smooth-muscle-type alpha-tropomyosins by using an alternative mRNA-splicing mechanism.