Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.
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Wang X, Lee G, Liebhaber SA, Cooke NE
Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.
J Biol Chem. 1992 May 5;267(13):9176-84.
- PubMed ID
- 1374386 [ View in PubMed]
- Abstract
We previously reported the structure of the placentally derived human cysteine-rich (h crp) cDNA and demonstrated that it encodes a highly conserved and widely distributed zinc finger-like protein. We now report that the expression of both the mouse and human crp genes is induced as a primary response to serum in quiescent Balb/c 3T3 cells and in human fibroblasts. The profile of this primary response is remarkably parallel to that of c-myc in the Balb/c 3T3 cell line. The structure of the 23.2-kilobase h crp gene demonstrates that it is a member of a gene superfamily encoding proteins sharing a highly characteristic 52-amino acid "LIM/double-finger" motif. The evolutionarily conserved structure of cysteine-rich protein, its structural similarity to a number of developmentally critical proteins, its distinctive tissue distribution, and its primary response to early events in the cell cycle suggest that crp plays an important role in cell function.