Identification of novel nuclear protein interactions with the N-terminal part of filamin A.
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Qiu H, Nomiyama R, Moriguchi K, Fukada T, Sugimoto K
Identification of novel nuclear protein interactions with the N-terminal part of filamin A.
Biosci Biotechnol Biochem. 2011;75(1):145-7. Epub 2011 Jan 7.
- PubMed ID
- 21228480 [ View in PubMed]
- Abstract
Since certain missense mutations in the N-terminal part of filamin A (FLNA) cause inherited skeletal malformation, we screened for proteins that bind to this part of FLNA. We identified two nuclear proteins that are specifically associated with the N-terminal region of FLNA. This suggests more extensive nuclear function of filamin than expected.