Hb F-Columbus-Ga or alpha 2 G gamma 2 94(FGl) Asp replaced by Asn.
Article Details
- CitationCopy to clipboard
Nakatsuji T, Lam H, Wilson JB, Webber BB, Huisman TH
Hb F-Columbus-Ga or alpha 2 G gamma 2 94(FGl) Asp replaced by Asn.
Hemoglobin. 1982;6(6):593-8.
- PubMed ID
- 6186636 [ View in PubMed]
- Abstract
A new gamma chain variant with an electrophoretic mobility at pH 8.1 between those of Hb S and Hb C was isolated and quantitated by DEAE-cellulose chromatography. It was readily identified with the use of various micro-chromatographic and sequencing procedures as alpha 2 G gamma 2 94(FGl)Asp replaced by Asn. The hemoglobin was named Hb F-Columbus-Ga. The quantity of this G gamma chain variant (as % total gamma chain) was about 39% and the percentages of the normal G gamma and A gamma I chains were 37% and 24%, respectively.