Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.
Article Details
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Jackson CJ, Lamb DC, Kelly DE, Kelly SL
Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.
FEMS Microbiol Lett. 2000 Nov 15;192(2):159-62.
- PubMed ID
- 11064188 [ View in PubMed]
- Abstract
Azole antifungals are central to therapy and act by inhibiting a cytochrome P450, sterol 14-demethylase and blocking normal sterol synthesis. Our recent identification of a mycobacterial sterol biosynthetic pathway led us to probe the efficacy of a range of these compounds against Mycobacterium smegmatis. Several showed equivalent or greater inhibitory effects to those against Candida albicans, and bactericidal activity was demonstrated for four compounds, clotrimazole, econazole, miconazole and tebuconazole. The major drug used clinically, fluconazole, was ineffective. The results are discussed in the light of the world-wide spread of tuberculosis, including drug-resistant forms and the requirement for new drugs.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Econazole Cytochrome P450 51 Protein Yeast YesAntagonistDetails