The metabolic fate of prazosin.

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Taylor JA, Twomey TM, von Wittenau MS

The metabolic fate of prazosin.

Xenobiotica. 1977 Jun;7(6):357-64. doi: 10.3109/00498257709035794.

PubMed ID
610052 [ View in PubMed
]
Abstract

1. [2-14C]Prazosin is rapidly distributed into tissues of the dog including heart, lung and vascular tissues. 2. Urinary excretion by rats and dogs is low, biliary secretion being the major route of elimination. 3. Biotransformation of prazosin in the rat and dog occurs primarily by 6- or 7-O-dealkylation and subsequent glucuronide formation, and to a lesser extent via N-dealkylation. 4. Preliminary metabolic studies in man indicate a pattern of metabolites similar to that observed in dogs and rats.

DrugBank Data that Cites this Article

Drug Reactions
Reaction
Prazosin
DB00457
    6-O-demethyl prazosin
    DBMET02344
    7-O-demethyl prazosin
    DBMET02345
    		Details
    Prazosin
    DB00457
      2,4-diamino-6,7-dimethoxyquinazoline
      DBMET00691
      2-(l-Piperazinyl)- 4-amino-6,7 - dimethoxyquinazoline
      DBMET02351
      		Details