Relationships among GnRH, substance P, prostaglandins, sex steroids and aromatase activity in the brain of the male lizard Podarcis sicula sicula during reproduction.

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Gobbetti A, Zerani M, Di Fiore MM, Botte V

Relationships among GnRH, substance P, prostaglandins, sex steroids and aromatase activity in the brain of the male lizard Podarcis sicula sicula during reproduction.

J Reprod Fertil. 1994 Aug;101(3):523-9.

PubMed ID

7525952 [ View in PubMed

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Abstract

The release of PGF2 alpha and PGE2, progesterone, androgens and oestradiol in vitro, and the aromatase activity in the brain of the male lizard Podarcis sicula sicula during three different phases of the reproductive period were evaluated. In addition, the effects of salmon GnRH, substance P, salmon GnRH antagonist, substance P antagonist, PGF2 alpha, PGE2 and acetylsalicylic acid on the release of prostaglandins and sex steroids and on aromatase activity in the brain were evaluated during the same three phases. PGF2 alpha, oestradiol and aromatase activity were higher during the refractory phase, androgens during the fighting phase, and progesterone during the mating phase, while PGE2 was lower during the refractory phase. Treatment with salmon GnRH increased PGF2 alpha, oestradiol and aromatase activity, but decreased the amount of androgens released. Substance P decreased PGF2 alpha, oestradiol and aromatase activity, but increased the amount of androgens released. PGF2 alpha increased oestradiol and aromatase activity, but decreased the amount of androgens released. Acetylsalicylic acid decreased PGF2 alpha, oestradiol and aromatase activity, but increased the amount of androgens released. These data suggest that salmon GnRH and substance P have different roles in reproductive processes, with opposite mechanisms, in the central nervous system of this male lizard: salmon GnRH seems to be involved in regulating the refractory phase, while substance P plays a role in regulating the fighting phase.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Sar9, Met (O2)11-Substance P	Cytochrome P450 19A1	Protein	Humans	Unknown	Inhibitor	Details