Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
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Cozza G, Bonvini P, Zorzi E, Poletto G, Pagano MA, Sarno S, Donella-Deana A, Zagotto G, Rosolen A, Pinna LA, Meggio F, Moro S
Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
J Med Chem. 2006 Apr 20;49(8):2363-6.
- PubMed ID
- 16610779 [ View in PubMed]
- Abstract
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor. At present, ellagic acid represents the most potent known CK2 inhibitor (K(i) = 20 nM).
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ellagic acid Casein kinase II subunit alpha Protein Humans UnknownInhibitorDetails Ellagic acid Tyrosine-protein kinase SYK Protein Humans UnknownInhibitorDetails