Clavulanic acid: a review.
Article Details
- CitationCopy to clipboard
Saudagar PS, Survase SA, Singhal RS
Clavulanic acid: a review.
Biotechnol Adv. 2008 Jul-Aug;26(4):335-51. doi: 10.1016/j.biotechadv.2008.03.002. Epub 2008 Mar 26.
- PubMed ID
- 18450406 [ View in PubMed]
- Abstract
Natural antibiotics are almost universal secondary metabolites, not essential for the growth of the producing organisms generally produced at low growth rates or after growth has ceased. Clavulanic acid (CA), a naturally occurring powerful inhibitor of bacterial beta-lactamases is a major beta-lactam antibiotic produced by organism Streptomyces clavuligerus and is active against a wide spectrum of Gram-positive and Gram-negative bacteria. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of CA.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Clavulanic acid Bacterial beta-lactamase enzymes Group YesInhibitorDetails